Effects of stimulants on ADHD and tic symptoms compared with placebo
| Authors | Years | No. of participants | Age range (yr) | Study duration | Drug | Control | Results |
|---|---|---|---|---|---|---|---|
| Castellanos et al. [22] | 1997 | 20 | 9.4 (mean age) | 9 weeks | MPH 15, 25, 45 mg bid AMP 7.5, 15, 22.5 mg bid | Placebo | ADHD symptoms improved without aggravation of tics |
| Nolan et al. [25] | 1999 | 19 | 12.3 (mean 6 weeks age) | 6 weeks | MPH 0.57 mg/kg (mean total daily dose) AMP 5, 10 mg bid |
Placebo | ADHD symptoms improved without aggravation of tics |
| Tourette’s Syndrome Study Group [24] | 2002 | 136 | 7-14 | 16 weeks | MPH+Clonidine MPH only Clonidine only | Placebo | ADHD symptoms improved without aggravation of tics |
| Gadow et al. [23] | 2007 | 71 | 6-12 | 15 years | MPH 0.1, 0.3, 0.5 mg/kg | Placebo | ADHD symptoms improved without aggravation of tics |
ADHD, attention deficit hyperactivity disorder; AMP, amphetamine; MPH, methylphenidate
