Journal of the Korean Academy of Child and Adolescent Psychiatry : eISSN 2233-9183 / pISSN 1225-729X

Table. 1.

Table. 1.

Effects of stimulants on ADHD and tic symptoms compared with placebo

Authors Years No. of participants Age range (yr) Study duration Drug Control Results
Castellanos et al. [22] 1997 20 9.4 (mean age) 9 weeks MPH 15, 25, 45 mg bid AMP 7.5, 15, 22.5 mg bid Placebo ADHD symptoms improved without aggravation of tics
Nolan et al. [25] 1999 19 12.3 (mean 6 weeks age) 6 weeks MPH 0.57 mg/kg (mean total daily dose)
AMP 5, 10 mg bid
Placebo ADHD symptoms improved without aggravation of tics
Tourette’s Syndrome Study Group [24] 2002 136 7-14 16 weeks MPH+Clonidine MPH only Clonidine only Placebo ADHD symptoms improved without aggravation of tics
Gadow et al. [23] 2007 71 6-12 15 years MPH 0.1, 0.3, 0.5 mg/kg Placebo ADHD symptoms improved without aggravation of tics

ADHD, attention deficit hyperactivity disorder; AMP, amphetamine; MPH, methylphenidate

J Korean Acad Child Adolesc Psychiatry 2022;33:27-34 https://doi.org/10.5765/jkacap.210034
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