Journal of the Korean Academy of Child and Adolescent Psychiatry : eISSN 2233-9183 / pISSN 1225-729X

Table. 2.

Table. 2.

Comparison of clinical and neuropsychological characteristics between responders and non-responders to atomoxetine

Responders (n=33) Mean (SD) Non-responders (n=32) Mean (SD) t p
ARS (pre-treatment)
 Inattentive 17.5 (3.4) 17.5 (4.4) -0.046 0.963
 Hyperactive-impulsive 12.6 (4.9) 12.0 (5.8) 0.412 0.682
CGI-S (pre-treatment) 5.2 (0.6) 5.1 (1.0) 0.284 0.778
KPRC (pre-treatment)
 Ego-resilience 47.4 (13.5) 46.0 (11.8) 0.453 0.652
 Verbal development 54.9 (12.8) 55.3 (9.8) -0.110 0.913
 Physical development 55.0 (13.0) 53.9 (8.7) 0.398 0.692
 Anxiety 50.4 (9.3) 50.4 (11.5) -0.005 0.996
 Depression 52.0 (10.4) 54.7 (9.7) -1.073 0.287
 Somatic concern 44.9 (8.5) 47.3 (6.9) -1.285 0.203
 Delinquency 56.9 (11.8) 59.8 (10.8) -1.058 0.294
 Hyperactivity 63.0 (9.5) 62.0 (12.1) 0.395 0.694
 Family dysfunction 52.4 (13.4) 54.5 (14.3) -0.595 0.554
 Social dysfunction 47.8 (8.6) 53.4 (10.3) -2.367 0.021*
 Psychoticism 56.7 (12.2) 57.3 (12.4) -0.221 0.825
ATA (pre-treatment)
 Omission errors, visual 5.1 (7.1) 4.8 (3.9) 0.201 0.841
 Commission errors, visual 3.0 (3.4) 5.0 (3.8) -2.140 0.036*
 Reaction time, visual 1.5 (1.9) 0.7 (1.5) 1.875 0.065
 Reaction time variability, visual 3.4 (4.4) 3.1 (2.3) 0.383 0.703
 Omission errors, auditory 1.9 (2.7) 1.4 (1.9) 0.805 0.424
 Commission errors, auditory 2.1 (2.3) 2.5 (3.2) -0.614 0.542
 Reaction time, auditory -0.5 (1.3) -2.2 (6.5) 1.447 0.153
 Reaction time variability, auditory 0.3 (1.4) 0.1 (1.1) 0.361 0.720

Definition of response to atomoxetine was determined as reduction in ARS score of more than 50% between pre-treatment and post-treatment (12th week) or less than three in Clinical Global Impression-Improvement scale score at post-treatment (12th week).

p<0.05. ARS: attention-deficit/hyperactivity disorder Rating Scale, ATA: Advanced Test of Attention, CGI-S: Clinical Global Impression-Severity scale, KPRC: Korean Personality Rating scale for Children, SD: standard deviation

J Korean Acad Child Adolesc Psychiatry 2019;30:74-82 https://doi.org/10.5765/jkacap.180030
© 2019 J Korean Acad Child Adolesc Psychiatry